Highlight
Integrating signals to drive type VI secretion system killing
Patricia Bernal,
Marina Murillo-Torres,
Luke P. Allsopp,
Patricia Bernal
Departamento de Microbiología, Facultad de Biología, Universidad de Sevilla, Seville, Spain
Search for more papers by this authorMarina Murillo-Torres
Departamento de Microbiología, Facultad de Biología, Universidad de Sevilla, Seville, Spain
National Heart and Lung Institute, Imperial College London, London, UK
Search for more papers by this authorCorresponding Author
Luke P. Allsopp
National Heart and Lung Institute, Imperial College London, London, UK
For correspondence. E-mail [email protected]; Tel. (+44) 020 7594 7829; Fax +44(0)20 7594 3069.Search for more papers by this authorPatricia Bernal,
Marina Murillo-Torres,
Luke P. Allsopp,
Patricia Bernal
Departamento de Microbiología, Facultad de Biología, Universidad de Sevilla, Seville, Spain
Search for more papers by this authorMarina Murillo-Torres
Departamento de Microbiología, Facultad de Biología, Universidad de Sevilla, Seville, Spain
National Heart and Lung Institute, Imperial College London, London, UK
Search for more papers by this authorCorresponding Author
Luke P. Allsopp
National Heart and Lung Institute, Imperial College London, London, UK
For correspondence. E-mail [email protected]; Tel. (+44) 020 7594 7829; Fax +44(0)20 7594 3069.Search for more papers by this author
References
- Allsopp, L.P., Bernal, P., Nolan, L.M., and Filloux, A. (2020) Causalities of war: the connection between type VI secretion system and microbiota. Cell Microbiol 22: 1–9.
- Allsopp, L.P., Wood, T.E., Howard, S.A., Maggiorelli, F., Nolan, L.M., Wettstadt, S., and Filloux, A. (2017) RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 114: 7707–7712.
- Bachmann, V., Kostiuk, B., Unterweger, D., Diaz-Satizabal, L., Ogg, S., and Pukatzki, S. (2015) Bile salts modulate the mucin-activated type VI secretion system of pandemic Vibrio cholerae. PLoS Negl Trop Dis 9: 1–22.
- Basler, M. (2015) Type VI secretion system: secretion by a contractile nanomachine. Philos Trans R Soc Lond B Biol Sci 370: 20150021.
- Bernard, C.S., Brunet, Y.R., Gavioli, M., Lloubès, R., and Cascales, E. (2011) Regulation of type VI secretion gene clusters by σ54 and cognate enhancer binding proteins. J Bacteriol 193: 2158–2167.
- Borgeaud, S., Metzger, L.C., Scrignari, T., and Blokesch, M. (2015) The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer. Science 347: 63–67.
- Browning, D.F., and Busby, S.J.W. (2004) The regulation of bacterial transcription initiation. Nat Rev Microbiol 2: 57–65.
- Chien, C.F., Liu, C.Y., Lu, Y.Y., Sung, Y.H., Chen, K.Y., and Lin, N.C. (2020) HSI-II gene cluster of Pseudomonas syringae pv. tomato DC3000 encodes a functional type VI secretion system required for interbacterial competition. Front Microbiol 11: 1–14.
- Crisan, C.V., and Hammer, B.K. (2020) The Vibrio cholerae type VI secretion system: toxins, regulators and consequences. Environ Microbiol. https://sfamjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/1462-2920.14976
- Dong, T.G., and Mekalanos, J.J. (2012) Characterization of the RpoN regulon reveals differential regulation of T6SS and new flagellar operons in Vibrio cholerae O37 strain V52. Nucleic Acids Res 40: 7766–7775..
- Francke, C., Groot Kormelink, T., Hagemeijer, Y., Overmars, L., Sluijter, V., Moezelaar, R., and Siezen, R.J. (2011) Comparative analyses imply that the enigmatic sigma factor 54 is a central controller of the bacterial exterior. BMC Genomics 12: 385.
- Gonzalez, D., and Mavridou, D.A.I. (2019) Making the best of aggression: the many dimensions of bacterial toxin regulation. Trends Microbiol 27: 897–905.
- Guckes, K.R., Cecere, A.G., Williams, A.L., McNeil, A.E., and Miyashiro, T. (2020) The bacterial enhancer binding protein VasH promotes expression of a type VI secretion system in Vibrio fischeri during symbiosis. J Bacteriol 202: 1–15.
- Ishikawa, T., Sabharwal, D., Bröms, J., Milton, D.L., Sjöstedt, A., Uhlin, B.E., and Wai, S.N. (2012) Pathoadaptive conditional regulation of the type VI secretion system in Vibrio cholerae O1 strains. Infect Immun 80: 575–584.
- Kitaoka, M., Miyata, S.T., Brooks, T.M., Unterweger, D., and Pukatzki, S. (2011) VasH is a transcriptional regulator of the type VI secretion system functional in endemic and pandemic Vibrio cholerae. J Bacteriol 193: 6471–6482.
- Le Roux, M., Kirkpatrick, R.L., Montauti, E.I., Tran, B.Q., Brook Peterson, S., Harding, B.N., et al. (2015) Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa. Elife 2015: 1–65.
- Pukatzki, S., Ma, A.T., Sturtevant, D., Krastins, B., Sarracino, D., Nelson, W.C., et al. (2006) Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci U S A 103: 1528–1533.
- Sana, T.G., Soscia, C., Tonglet, C.M., Garvis, S., and Bleves, S. (2013) Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa. PLoS One 8: 1–10.
- Schaefer, J., Engl, C., Zhang, N., Lawton, E., and Buck, M. (2015) Genome wide interactions of wild-type and activator bypass forms of σ54. Nucleic Acids Res 43: 7280–7291.
- Schumacher, J., Joly, N., Rappas, M., Zhang, X., and Buck, M. (2006) Structures and organisation of AAA+ enhancer binding proteins in transcriptional activation. J Struct Biol 156: 190–199.
- Seibt, H., Aung, K.M., Ishikawa, T., Sjöström, A., Gullberg, M., Atkinson, G.C., et al. (2020) Elevated levels of VCA0117 (VasH) in response to external signals activate the type VI secretion system of Vibrio cholerae O1 El Tor A1552. Environ Microbiol. https://sfamjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/1462-2920.15141
- Silverman, J.M., Brunet, Y.R., Cascales, E., and Mougous, J.D. (2012) Structure and regulation of the type VI secretion system. Annu Rev Microbiol 66: 453–472.
- Speare, L., Cecere, A.G., Guckes, K.R., Smith, S., Wollenberg, M.S., Mandel, M.J., et al. (2018) Bacterial symbionts use a type VI secretion system to eliminate competitors in their natural host. Proc Natl Acad Sci U S A 115: E8528–E8537.
- Storey, D., McNally, A., Åstrand, M., Santos, J.P.G., Rodriguez-Escudero, I., Elmore, B., et al. (2020) Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent. PLoS Pathog 16: e1007969.
- Wang, J., Brodmann, M., and Basler, M. (2019) Assembly and subcellular localization of bacterial type VI secretion systems. Annu Rev Microbiol 73: 621–638.
- Wu, C.F., Lin, J.S., Shaw, G.C., and Lai, E.M. (2012) Acid-induced type VI secretion system is regulated by ExoR-ChvG/ChvI signaling cascade in Agrobacterium tumefaciens. PLoS Pathog 8: e1002938.
- Zheng, J., Ho, B., and Mekalanos, J.J. (2011) Genetic analysis of anti-amoebae and anti-bacterial activities of the type vi secretion system in Vibrio cholerae. PLoS One 6: e23876.
