Volume 10, Issue 2 p. 140-154
Minireview

The metabolic pathways utilized by Salmonella Typhimurium during infection of host cells

Arthur Thompson

Arthur Thompson

Institute for Food Research, Norwich Research Park, Norwich NR4 7UA, UK

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Marcus Fulde

Marcus Fulde

Centre for Infection Medicine, Institute of Microbiology and Epizootics, Freie Universität Berlin, 14163 Berlin, Germany

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Karsten Tedin

Corresponding Author

Karsten Tedin

Centre for Infection Medicine, Institute of Microbiology and Epizootics, Freie Universität Berlin, 14163 Berlin, Germany

For correspondence. E-mail [email protected]; Tel. (+49) 30 838 59705; Fax (+49) 30 838 451 851.Search for more papers by this author
First published: 06 February 2018
Citations: 20

Summary

Only relatively recently has research on the metabolism of intracellular bacterial pathogens within their host cells begun to appear in the published literature. This reflects in part the experimental difficulties encountered in separating host metabolic processes from those of the resident pathogen. One of the most genetically tractable and thoroughly studied intracellular bacterial pathogens, Salmonella enterica serovar Typhimurium (S. Typhimurium), has been at the forefront of metabolic studies within eukaryotic host cells. In this review, we offer a synthesis of what has been discovered to date regarding the metabolic adaptation of S. Typhimurium to survival and growth within the infected host. We discuss many studies in the context of techniques used, types of host cells, how host metabolites contribute to intracellular survival and proliferation of the pathogen and how bacterial metabolism affects the virulence and persistence of the pathogen.